Alkyne-mediated domino hydroformylation/double cyclization: mechanistic insight and synthesis of (±)-tashiromine.
نویسندگان
چکیده
A novel domino reaction, alkyne-mediated domino hydroformylation/double cyclization, has been developed for rapid preparation of indolizidine type alkaloids. DFT calculations were applied for rationales of reactivity and selectivity. A concise synthesis of tashiromine as the application of the methodology is also reported.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 47 12 شماره
صفحات -
تاریخ انتشار 2011