Alkyne-mediated domino hydroformylation/double cyclization: mechanistic insight and synthesis of (±)-tashiromine.

نویسندگان

  • Wen-Hua Chiou
  • Yi-Huei Lin
  • Guei-Tang Chen
  • Yu-Kai Gao
  • Yu-Che Tseng
  • Chien-Lun Kao
  • Jui-Chi Tsai
چکیده

A novel domino reaction, alkyne-mediated domino hydroformylation/double cyclization, has been developed for rapid preparation of indolizidine type alkaloids. DFT calculations were applied for rationales of reactivity and selectivity. A concise synthesis of tashiromine as the application of the methodology is also reported.

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عنوان ژورنال:
  • Chemical communications

دوره 47 12  شماره 

صفحات  -

تاریخ انتشار 2011